Assay Detail
Binding
CHEMBL4028335
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Displacement of [125I]CXCL12 from human CXCR4 expressed in HEK293 cell membranes after 1.5 hrs by Topcount method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.01 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068500 | — | — | 1 | 7.62 |
| CHEMBL4060426 | — | — | 1 | 7.59 |
| CHEMBL4070263 | — | — | 1 | 7.47 |
| CHEMBL4064397 | — | — | 1 | 7.47 |
| CHEMBL4091201 | — | — | 1 | 7.33 |
| CHEMBL4078499 | — | — | 1 | 7.32 |
| CHEMBL4075454 | — | — | 1 | 7.21 |
| CHEMBL4098404 | — | — | 1 | 7.15 |
| CHEMBL4090175 | — | — | 1 | 7.15 |
| CHEMBL4068647 | — | — | 1 | 7.14 |
| CHEMBL4089763 | — | — | 1 | 7.14 |
| CHEMBL4102780 | — | — | 1 | 7.14 |
| CHEMBL4082328 | — | — | 1 | 7.09 |
| CHEMBL4104222 | — | — | 1 | 7.08 |
| CHEMBL4079981 | — | — | 1 | 7.05 |
| CHEMBL4081892 | — | — | 1 | 7.04 |
| CHEMBL4069110 | — | — | 1 | 7.03 |
| CHEMBL4079460 | — | — | 1 | 7.01 |
| CHEMBL4059987 | — | — | 1 | 6.83 |
| CHEMBL4071355 | — | — | 1 | 6.80 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 6.67 |
| CHEMBL4097496 | — | — | 1 | 6.40 |
| CHEMBL4083415 | — | — | 1 | 6.33 |
| CHEMBL4099856 | — | — | 1 | 6.15 |
| CHEMBL4072978 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068500 | — | IC50 | = | 23.9 | nM | 7.62 |
| CHEMBL4060426 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL4070263 | — | IC50 | = | 34.1 | nM | 7.47 |
| CHEMBL4064397 | — | IC50 | = | 34.2 | nM | 7.47 |
| CHEMBL4091201 | — | IC50 | = | 46.8 | nM | 7.33 |
| CHEMBL4078499 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL4075454 | — | IC50 | = | 61.1 | nM | 7.21 |
| CHEMBL4098404 | — | IC50 | = | 71.1 | nM | 7.15 |
| CHEMBL4090175 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL4068647 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4089763 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL4102780 | — | IC50 | = | 72.1 | nM | 7.14 |
| CHEMBL4082328 | — | IC50 | = | 81.8 | nM | 7.09 |
| CHEMBL4104222 | — | IC50 | = | 82.6 | nM | 7.08 |
| CHEMBL4079981 | — | IC50 | = | 88.5 | nM | 7.05 |
| CHEMBL4081892 | — | IC50 | = | 91.6 | nM | 7.04 |
| CHEMBL4069110 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4079460 | — | IC50 | = | 97.6 | nM | 7.01 |
| CHEMBL4059987 | — | IC50 | = | 147.1 | nM | 6.83 |
| CHEMBL4071355 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 213.1 | nM | 6.67 |
| CHEMBL4097496 | — | IC50 | = | 399.3 | nM | 6.40 |
| CHEMBL4083415 | — | IC50 | = | 472.7 | nM | 6.33 |
| CHEMBL4099856 | — | IC50 | = | 708.3 | nM | 6.15 |
| CHEMBL4072978 | — | IC50 | = | 859.7 | nM | 6.07 |