Assay Detail
Functional
CHEMBL4028411
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Antileishmanial activity against Leishmania major MHOM/IL/80/Friedlin promastigotes after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.97 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095630 | — | — | 1 | 7.47 |
| CHEMBL4087746 | — | — | 1 | 6.74 |
| CHEMBL4079866 | — | — | 1 | 6.61 |
| CHEMBL4095443 | — | — | 1 | 6.51 |
| CHEMBL4068055 | — | — | 1 | 6.27 |
| CHEMBL4105628 | — | — | 1 | 6.04 |
| CHEMBL4097889 | — | — | 1 | 5.98 |
| CHEMBL2349416 | PYRIDOSTATIN | — | 1 | 5.30 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.22 |
| CHEMBL336434 | — | — | 1 | 4.89 |
| CHEMBL2170855 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095630 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4087746 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4079866 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4095443 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL4068055 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL4105628 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL4097889 | — | IC50 | = | 1041.0 | nM | 5.98 |
| CHEMBL2349416 | PYRIDOSTATIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 6070.0 | nM | 5.22 |
| CHEMBL336434 | — | IC50 | = | 12730.0 | nM | 4.89 |
| CHEMBL2170855 | — | IC50 | = | 20820.0 | nM | 4.68 |