Assay Detail
ADMET
CHEMBL4028412
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Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.89 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095630 | — | — | 1 | 6.44 |
| CHEMBL4097889 | — | — | 1 | 6.29 |
| CHEMBL4068055 | — | — | 1 | 6.15 |
| CHEMBL4095443 | — | — | 1 | 6.09 |
| CHEMBL4087746 | — | — | 1 | 6.04 |
| CHEMBL4079866 | — | — | 1 | 5.94 |
| CHEMBL4105628 | — | — | 1 | 5.69 |
| CHEMBL2349416 | PYRIDOSTATIN | — | 1 | 5.27 |
| CHEMBL336434 | — | — | 1 | 5.08 |
| CHEMBL2170855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095630 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4097889 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4068055 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4095443 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4087746 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4079866 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4105628 | — | IC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL2349416 | PYRIDOSTATIN | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL336434 | — | IC50 | = | 8330.0 | nM | 5.08 |
| CHEMBL2170855 | — | IC50 | > | 25000.0 | nM | - |