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Assay Detail

CHEMBL4028443

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Pseudomonas aeruginosa metallobeta-lactamase-2 expressed in Escherichia coli by fluorogenic assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Pseudomonas aeruginosa
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-lactamase VIM-2 (CHEMBL5798)
Type SINGLE PROTEIN
Organism Pseudomonas aeruginosa

Publication

X-ray Structures of Target-Ligand Complexes Containing Compounds with Assay Interference Potential.
Gilberg E, Gütschow M, Bajorath J.
J Med Chem (2018) 61 : 1276 -1284
PubMed 29328660 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.30 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4068716 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4068716 IC50 = 498.0 nM 6.30