Assay Detail
Functional
CHEMBL4028453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against oseltamivir/amantadine-resistant Influenza A virus (A/California/07/2009(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in plaque formation after 2 days by crystal violet staining based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/California/07/2009(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.18 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770006 | — | — | 1 | 7.00 |
| CHEMBL3771213 | — | — | 1 | 7.00 |
| CHEMBL3769492 | — | — | 1 | 6.70 |
| CHEMBL4061288 | — | — | 1 | 6.52 |
| CHEMBL3088160 | — | — | 1 | 6.52 |
| CHEMBL4078401 | — | — | 1 | 6.30 |
| CHEMBL3770341 | — | — | 1 | 6.30 |
| CHEMBL4077388 | — | — | 1 | 6.22 |
| CHEMBL4084941 | — | — | 1 | 6.16 |
| CHEMBL4077438 | — | — | 1 | 6.10 |
| CHEMBL4077296 | — | — | 1 | 6.10 |
| CHEMBL3770326 | — | — | 1 | 6.00 |
| CHEMBL4068854 | — | — | 1 | 5.77 |
| CHEMBL4062654 | — | — | 1 | 5.58 |
| CHEMBL4064005 | — | — | 1 | 5.51 |
| CHEMBL4075960 | — | — | 1 | 5.17 |
| CHEMBL4076108 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770006 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3771213 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3769492 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4061288 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3088160 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4078401 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3770341 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4077388 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4084941 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4077438 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4077296 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3770326 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4068854 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4062654 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4064005 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4075960 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4076108 | — | EC50 | > | 30000.0 | nM | - |