Assay Detail
Functional
CHEMBL4028485
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic antiviral activity against Influenza A virus (A/WSN/33(H1N1)) infected in MDCK cells expressing ST6Gal-1 assessed as reduction in virus-induced cytopathic effect after 44 to 48 hrs in presence of 5:1 3-{[(5-Cyclopropyl-1,2-oxazol-3-yl)methyl]amino}adamantan-1-ol to compound molar ratio by neutral red staining based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/WSN/1933(H1N1)) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 9.96 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 9.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 0.11 | nM | 9.96 |