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Assay Detail

CHEMBL4028611

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Functional
Antiviral activity against Coxsackievirus B3 infected in human HeLa-RW cells assessed as protection against virus-induced cytopathic effect after 3 to 4 days by crystal violet staining-based spectrophotometric method
ChEMBL ↗
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Coxsackievirus B3
Confidence 1 — Organism
Curated By Autocuration

Target

Coxsackievirus B3 (CHEMBL613554) ↗
Type ORGANISM
Organism Coxsackievirus B3

Publication

Synthesis and Structure-Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication.
Xing Y, Zuo J, Krogstad P, Jung ME.
J Med Chem (2018) 61 : 1688 -1703
PubMed 29346733 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 66 5.81 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4073705 — — 1 6.40
CHEMBL4089908 — — 1 6.30
CHEMBL4074907 — — 1 6.22
CHEMBL4078434 — — 1 6.22
CHEMBL4103103 — — 1 6.22
CHEMBL4085160 — — 1 6.22
CHEMBL4089590 — — 1 6.16
CHEMBL4063169 — — 1 6.16
CHEMBL4065649 — — 1 6.16
CHEMBL4064163 — — 1 6.16
CHEMBL4081448 — — 1 6.16
CHEMBL4095169 — — 1 6.10
CHEMBL4095351 — — 1 6.10
CHEMBL4062242 — — 1 6.10
CHEMBL4068869 — — 1 6.00
CHEMBL4092902 — — 1 6.00
CHEMBL4061842 — — 1 5.96
CHEMBL4103777 — — 1 5.92
CHEMBL4076793 — — 1 5.92
CHEMBL4104324 — — 1 5.92
CHEMBL4070731 — — 1 5.89
CHEMBL4089323 — — 1 5.89
CHEMBL4087654 — — 1 5.89
CHEMBL4097337 — — 1 5.89
CHEMBL4082479 — — 1 5.85
CHEMBL4097023 — — 1 5.85
CHEMBL4075038 — — 1 5.80
CHEMBL4090252 — — 1 5.75
CHEMBL4097829 — — 1 5.72
CHEMBL4076567 — — 1 5.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4073705 — EC50 = 400.0 nM 6.40
CHEMBL4089908 — EC50 = 500.0 nM 6.30
CHEMBL4078434 — EC50 = 600.0 nM 6.22
CHEMBL4103103 — EC50 = 600.0 nM 6.22
CHEMBL4085160 — EC50 = 600.0 nM 6.22
CHEMBL4074907 — EC50 = 600.0 nM 6.22
CHEMBL4089590 — EC50 = 700.0 nM 6.16
CHEMBL4063169 — EC50 = 700.0 nM 6.16
CHEMBL4065649 — EC50 = 700.0 nM 6.16
CHEMBL4064163 — EC50 = 700.0 nM 6.16
CHEMBL4081448 — EC50 = 700.0 nM 6.16
CHEMBL4062242 — EC50 = 800.0 nM 6.10
CHEMBL4095351 — EC50 = 800.0 nM 6.10
CHEMBL4095169 — EC50 = 800.0 nM 6.10
CHEMBL4092902 — EC50 = 1000.0 nM 6.00
CHEMBL4068869 — EC50 = 1000.0 nM 6.00
CHEMBL4061842 — EC50 = 1100.0 nM 5.96
CHEMBL4103777 — EC50 = 1200.0 nM 5.92
CHEMBL4076793 — EC50 = 1200.0 nM 5.92
CHEMBL4104324 — EC50 = 1200.0 nM 5.92
CHEMBL4070731 — EC50 = 1300.0 nM 5.89
CHEMBL4089323 — EC50 = 1300.0 nM 5.89
CHEMBL4087654 — EC50 = 1300.0 nM 5.89
CHEMBL4097337 — EC50 = 1300.0 nM 5.89
CHEMBL4097023 — EC50 = 1400.0 nM 5.85
CHEMBL4082479 — EC50 = 1400.0 nM 5.85
CHEMBL4075038 — EC50 = 1600.0 nM 5.80
CHEMBL4090252 — EC50 = 1800.0 nM 5.75
CHEMBL4097829 — EC50 = 1900.0 nM 5.72
CHEMBL4076567 — EC50 = 2200.0 nM 5.66
CHEMBL4070154 — EC50 = 2400.0 nM 5.62
CHEMBL4066299 — EC50 = 2600.0 nM 5.58
CHEMBL4101456 — EC50 = 2700.0 nM 5.57
CHEMBL4070860 — EC50 = 2700.0 nM 5.57
CHEMBL4091614 — EC50 = 3100.0 nM 5.51
CHEMBL4068138 — EC50 = 3200.0 nM 5.50
CHEMBL4080812 — EC50 = 3300.0 nM 5.48
CHEMBL4061494 — EC50 = 3300.0 nM 5.48
CHEMBL4100490 — EC50 = 4500.0 nM 5.35
CHEMBL4061957 — EC50 = 4700.0 nM 5.33
CHEMBL4101721 — EC50 = 4700.0 nM 5.33
CHEMBL4079095 — EC50 = 5100.0 nM 5.29
CHEMBL4097114 — EC50 = 6900.0 nM 5.16
CHEMBL4088681 — EC50 = 7000.0 nM 5.16
CHEMBL4085541 — EC50 = 9400.0 nM 5.03
CHEMBL4067444 — EC50 > 10000.0 nM -
CHEMBL4063123 — EC50 > 25000.0 nM -
CHEMBL4102866 — EC50 > 10000.0 nM -
CHEMBL4084916 — EC50 > 10000.0 nM -
CHEMBL4095469 — EC50 > 10000.0 nM -