Assay Detail
Functional
CHEMBL4028622
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HBV infected in human HepG2.2.15 replicon cells assessed as reduction in viral DNA level after 7 days by RT-PCR method
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-((R)-4-(((R)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 63 | 7.18 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078766 | — | — | 1 | 8.52 |
| CHEMBL4064672 | — | — | 1 | 8.32 |
| CHEMBL4076401 | — | — | 1 | 8.30 |
| CHEMBL4094822 | — | — | 1 | 8.30 |
| CHEMBL4063560 | — | — | 1 | 8.30 |
| CHEMBL4095407 | — | — | 1 | 8.24 |
| CHEMBL4074934 | — | — | 1 | 8.10 |
| CHEMBL4095001 | — | — | 1 | 8.07 |
| CHEMBL4059649 | — | — | 1 | 8.03 |
| CHEMBL4064808 | — | — | 1 | 8.01 |
| CHEMBL4061060 | — | — | 1 | 8.00 |
| CHEMBL4079166 | — | — | 1 | 7.96 |
| CHEMBL4087026 | — | — | 1 | 7.96 |
| CHEMBL3742114 | — | — | 1 | 7.89 |
| CHEMBL4079561 | — | — | 1 | 7.82 |
| CHEMBL4062770 | — | — | 1 | 7.80 |
| CHEMBL4092352 | — | — | 1 | 7.72 |
| CHEMBL4100106 | — | — | 1 | 7.68 |
| CHEMBL4091444 | — | — | 1 | 7.62 |
| CHEMBL4081602 | — | — | 1 | 7.55 |
| CHEMBL4075908 | — | — | 1 | 7.46 |
| CHEMBL4084810 | — | — | 1 | 7.44 |
| CHEMBL4102761 | — | — | 1 | 7.43 |
| CHEMBL4085181 | — | — | 1 | 7.41 |
| CHEMBL4070728 | — | — | 1 | 7.38 |
| CHEMBL4089481 | — | — | 1 | 7.37 |
| CHEMBL4097181 | — | — | 1 | 7.37 |
| CHEMBL4073176 | — | — | 1 | 7.33 |
| CHEMBL4087323 | — | — | 1 | 7.27 |
| CHEMBL4068300 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078766 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4064672 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4094822 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4063560 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4076401 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4095407 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4074934 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4095001 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4059649 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4064808 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4061060 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4079166 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4087026 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3742114 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4079561 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4062770 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4092352 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4100106 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4091444 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4081602 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4075908 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4084810 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4102761 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4085181 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4070728 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4089481 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4097181 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4073176 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4087323 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4068300 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4086134 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4077161 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4077526 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4096295 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4104048 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4101622 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4098434 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4103602 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4088287 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4087396 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4093889 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL4100564 | — | EC50 | = | 166.0 | nM | 6.78 |
| CHEMBL4078243 | — | EC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4064868 | — | EC50 | = | 263.0 | nM | 6.58 |
| CHEMBL4083668 | — | EC50 | = | 292.0 | nM | 6.54 |
| CHEMBL4103771 | — | EC50 | = | 486.0 | nM | 6.31 |
| CHEMBL4065913 | — | EC50 | = | 499.0 | nM | 6.30 |
| CHEMBL4074324 | — | EC50 | = | 914.0 | nM | 6.04 |
| CHEMBL4082545 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4092568 | — | EC50 | = | 2370.0 | nM | 5.62 |