Assay Detail
Binding
CHEMBL4028623
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by manual-patch-clamp electrophysiology assay
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-((R)-4-(((R)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 5.66 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4079561 | — | — | 1 | 6.77 |
| CHEMBL4103602 | — | — | 1 | 6.58 |
| CHEMBL4078766 | — | — | 1 | 6.52 |
| CHEMBL4082519 | — | — | 1 | 6.16 |
| CHEMBL3742114 | — | — | 1 | 6.07 |
| CHEMBL4077161 | — | — | 1 | 6.05 |
| CHEMBL4087396 | — | — | 1 | 5.97 |
| CHEMBL4088287 | — | — | 1 | 5.79 |
| CHEMBL4076401 | — | — | 1 | 5.64 |
| CHEMBL4075908 | — | — | 1 | 5.46 |
| CHEMBL4070728 | — | — | 1 | 5.42 |
| CHEMBL4062770 | — | — | 1 | 5.39 |
| CHEMBL4068707 | — | — | 1 | 5.38 |
| CHEMBL4064808 | — | — | 1 | 5.35 |
| CHEMBL4092509 | — | — | 1 | 5.31 |
| CHEMBL4067663 | — | — | 1 | 5.30 |
| CHEMBL4098434 | — | — | 1 | 5.24 |
| CHEMBL4102761 | — | — | 1 | 5.13 |
| CHEMBL4103771 | — | — | 1 | 5.06 |
| CHEMBL4100106 | — | — | 1 | 4.62 |
| CHEMBL4089481 | — | — | 1 | - |
| CHEMBL4068300 | — | — | 1 | - |
| CHEMBL4081602 | — | — | 1 | - |
| CHEMBL4059649 | — | — | 1 | - |
| CHEMBL4097181 | — | — | 1 | - |
| CHEMBL4104891 | — | — | 1 | - |
| CHEMBL4102843 | — | — | 1 | - |
| CHEMBL4084893 | — | — | 1 | - |
| CHEMBL4079517 | — | — | 1 | - |
| CHEMBL4060052 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4079561 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4103602 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4078766 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4082519 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3742114 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4077161 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4087396 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4088287 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4076401 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4075908 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL4070728 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4062770 | — | IC50 | = | 4040.0 | nM | 5.39 |
| CHEMBL4068707 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL4064808 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4092509 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4067663 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL4098434 | — | IC50 | = | 5740.0 | nM | 5.24 |
| CHEMBL4102761 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL4103771 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL4100106 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL4085181 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4063560 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4074324 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4094822 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4061060 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4092352 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4064672 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4073176 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4091444 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4061904 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4087026 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4068628 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4095407 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4095001 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4077526 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4101622 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4074934 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4093889 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4083668 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4096023 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4060052 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4079517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4084893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4102843 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4104891 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4097181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4059649 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4081602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4068300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4089481 | — | IC50 | > | 10000.0 | nM | - |