Assay Detail
Binding
CHEMBL4028679
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Inhibition of Clostridium botulinum BoNT/A light chain using P39 as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by HPLC method
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5192) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum |
Publication
New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.31 | 6.16 |
| Inhibition | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065254 | — | — | 2 | 6.16 |
| CHEMBL4091673 | — | — | 2 | 5.82 |
| CHEMBL4064938 | — | — | 2 | 5.57 |
| CHEMBL4098680 | — | — | 2 | 5.57 |
| CHEMBL4092916 | — | — | 2 | 5.52 |
| CHEMBL4061909 | — | — | 2 | 5.48 |
| CHEMBL4088496 | — | — | 2 | 5.47 |
| CHEMBL4092633 | — | — | 2 | 5.35 |
| CHEMBL4076269 | — | — | 2 | 5.34 |
| CHEMBL4095296 | — | — | 2 | 5.28 |
| CHEMBL4070794 | — | — | 2 | 5.24 |
| CHEMBL4080629 | — | — | 2 | 5.17 |
| CHEMBL4085175 | — | — | 2 | 5.13 |
| CHEMBL4088919 | — | — | 2 | 5.06 |
| CHEMBL4079717 | — | — | 2 | 5.06 |
| CHEMBL4060273 | — | — | 2 | 5.06 |
| CHEMBL4103981 | — | — | 2 | 5.03 |
| CHEMBL4095363 | — | — | 2 | 4.99 |
| CHEMBL4096220 | — | — | 2 | 4.93 |
| CHEMBL3264511 | — | — | 2 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065254 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4091673 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4064938 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4098680 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4092916 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4061909 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4088496 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4092633 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4076269 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4095296 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4070794 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4080629 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4085175 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4060273 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4088919 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4079717 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4103981 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4095363 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4096220 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3264511 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4070794 | — | Inhibition | - | % | - | |
| CHEMBL4091673 | — | Inhibition | - | % | - | |
| CHEMBL4092633 | — | Inhibition | - | % | - | |
| CHEMBL4064938 | — | Inhibition | - | % | - | |
| CHEMBL4065254 | — | Inhibition | - | % | - | |
| CHEMBL4092916 | — | Inhibition | - | % | - | |
| CHEMBL4085175 | — | Inhibition | - | % | - | |
| CHEMBL4095363 | — | Inhibition | - | % | - | |
| CHEMBL4076269 | — | Inhibition | - | % | - | |
| CHEMBL4061909 | — | Inhibition | - | % | - | |
| CHEMBL4088919 | — | Inhibition | - | % | - | |
| CHEMBL4088496 | — | Inhibition | - | % | - | |
| CHEMBL4060273 | — | Inhibition | - | % | - | |
| CHEMBL3264511 | — | Inhibition | - | % | - | |
| CHEMBL4080629 | — | Inhibition | - | % | - | |
| CHEMBL4103981 | — | Inhibition | - | % | - | |
| CHEMBL4098680 | — | Inhibition | - | % | - | |
| CHEMBL4079717 | — | Inhibition | - | % | - | |
| CHEMBL4095296 | — | Inhibition | - | % | - | |
| CHEMBL4096220 | — | Inhibition | - | % | - |