Assay Detail
Functional
CHEMBL4028748
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Cytotoxicity against human M14 cells after 72 hrs by MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M14 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.61 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095025 | — | — | 1 | 8.48 |
| CHEMBL4067605 | — | — | 1 | 8.38 |
| CHEMBL4102788 | — | — | 1 | 8.26 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.19 |
| CHEMBL4095734 | — | — | 1 | 7.73 |
| CHEMBL4088019 | — | — | 1 | 7.40 |
| CHEMBL4068389 | — | — | 1 | 7.38 |
| CHEMBL4105202 | — | — | 1 | 7.28 |
| CHEMBL4079240 | — | — | 1 | 7.28 |
| CHEMBL4075372 | — | — | 1 | 6.79 |
| CHEMBL4102747 | — | — | 1 | 6.57 |
| CHEMBL4087344 | — | — | 1 | - |
| CHEMBL4103488 | — | — | 1 | - |
| CHEMBL4079230 | — | — | 1 | - |
| CHEMBL4059730 | — | — | 1 | - |
| CHEMBL4094045 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095025 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4067605 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4102788 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4095734 | — | IC50 | = | 18.8 | nM | 7.73 |
| CHEMBL4088019 | — | IC50 | = | 39.5 | nM | 7.40 |
| CHEMBL4068389 | — | IC50 | = | 41.2 | nM | 7.38 |
| CHEMBL4105202 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL4079240 | — | IC50 | = | 52.6 | nM | 7.28 |
| CHEMBL4075372 | — | IC50 | = | 164.1 | nM | 6.79 |
| CHEMBL4102747 | — | IC50 | = | 268.9 | nM | 6.57 |
| CHEMBL4087344 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4103488 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4079230 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4059730 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4094045 | — | IC50 | > | 1000.0 | nM | - |