Assay Detail
Functional
CHEMBL4028773
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Cytotoxicity against human DU145-TxR cells after 72 hrs by MTS assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU145-TxR |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.08 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102788 | — | — | 1 | 7.70 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 6.45 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102788 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 352.3 | nM | 6.45 |
| CHEMBL107 | COLCHICINE | IC50 | > | 1000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 1000.0 | nM | - |