Assay Detail
Binding
CHEMBL4029972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP11B2-CLE9 expressed in Chinese hamster V79 cells using 11-deoxycorticosterone as substrate preincubated for 1 hr followed by substrate addition measured for 3 hrs by HTRF assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.49 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096914 | — | — | 1 | 9.70 |
| CHEMBL4069720 | — | — | 1 | 9.52 |
| CHEMBL4075377 | — | — | 1 | 9.05 |
| CHEMBL4080420 | — | — | 1 | 8.89 |
| CHEMBL4101709 | — | — | 1 | 8.70 |
| CHEMBL4067000 | — | — | 1 | 8.66 |
| CHEMBL4081339 | — | — | 1 | 8.12 |
| CHEMBL4061038 | — | — | 1 | 8.11 |
| CHEMBL4091491 | — | — | 1 | 7.96 |
| CHEMBL4098297 | — | — | 1 | 7.85 |
| CHEMBL4083708 | — | — | 1 | 7.82 |
| CHEMBL4089210 | — | — | 1 | 7.66 |
| CHEMBL4070125 | — | — | 1 | 7.60 |
| CHEMBL4075484 | — | — | 1 | 7.57 |
| CHEMBL4096817 | — | — | 1 | 7.51 |
| CHEMBL4080256 | — | — | 1 | 7.48 |
| CHEMBL4082750 | — | — | 1 | 7.47 |
| CHEMBL4063670 | — | — | 1 | 7.36 |
| CHEMBL4071689 | — | — | 1 | 7.11 |
| CHEMBL4085626 | — | — | 1 | 7.11 |
| CHEMBL4100151 | — | — | 1 | 7.07 |
| CHEMBL4078791 | — | — | 1 | 7.06 |
| CHEMBL4100299 | — | — | 1 | 7.01 |
| CHEMBL4067905 | — | — | 1 | 6.66 |
| CHEMBL4072268 | — | — | 1 | 6.52 |
| CHEMBL4089111 | — | — | 1 | 6.34 |
| CHEMBL4073305 | — | — | 1 | 6.29 |
| CHEMBL4063214 | — | — | 1 | 6.28 |
| CHEMBL4099223 | — | — | 1 | 6.12 |
| CHEMBL4099361 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096914 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4069720 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4075377 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4080420 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4101709 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4067000 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4081339 | — | IC50 | = | 7.58 | nM | 8.12 |
| CHEMBL4061038 | — | IC50 | = | 7.77 | nM | 8.11 |
| CHEMBL4091491 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4098297 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4083708 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4089210 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4070125 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4075484 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4096817 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4080256 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL4082750 | — | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL4063670 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4071689 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4085626 | — | IC50 | = | 78.5 | nM | 7.11 |
| CHEMBL4100151 | — | IC50 | = | 84.9 | nM | 7.07 |
| CHEMBL4078791 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4100299 | — | IC50 | = | 97.9 | nM | 7.01 |
| CHEMBL4067905 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4072268 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4089111 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL4073305 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL4063214 | — | IC50 | = | 528.0 | nM | 6.28 |
| CHEMBL4099223 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4099361 | — | IC50 | = | 1156.0 | nM | 5.94 |
| CHEMBL4076806 | — | IC50 | = | 2300.0 | nM | 5.64 |