Assay Detail
Binding
CHEMBL4029977
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Inhibition of CYP19 (unknown origin) using MFC as substrate and NADPH as cofactor preincubated for 10 mins with cofactor followed by substrate/enzyme addition measured after 30 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.24 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067000 | — | — | 1 | 5.34 |
| CHEMBL4071689 | — | — | 1 | 5.27 |
| CHEMBL4080256 | — | — | 1 | 5.21 |
| CHEMBL4098297 | — | — | 1 | 5.20 |
| CHEMBL4080420 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067000 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4071689 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4080256 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4098297 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4080420 | — | IC50 | = | 6900.0 | nM | 5.16 |