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Assay Detail

CHEMBL4030174

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of goat lenses ALR2 using glyceraldehyde as substrate measured for 5 mins by UV-spectrophotometric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Capra hircus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach.
Chadha N, Silakari O.
Bioorg Med Chem Lett (2017) 27 : 2324 -2330
PubMed 28438542 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.02 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56337 EPALRESTAT 4.0 1 7.05
CHEMBL4090218 1 5.77
CHEMBL4105580 1 5.33
CHEMBL4079898 1 5.18
CHEMBL4069154 1 4.94
CHEMBL4063888 1 4.86
CHEMBL4082372 1 4.81
CHEMBL1910509 1 4.78
CHEMBL4072184 1 4.64
CHEMBL4101990 1 4.64
CHEMBL4065625 1 4.61
CHEMBL4099515 1 4.40
CHEMBL4075239 1 4.31

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56337 EPALRESTAT IC50 = 90.0 nM 7.05
CHEMBL4090218 IC50 = 1700.0 nM 5.77
CHEMBL4105580 IC50 = 4720.0 nM 5.33
CHEMBL4079898 IC50 = 6570.0 nM 5.18
CHEMBL4069154 IC50 = 11490.0 nM 4.94
CHEMBL4063888 IC50 = 13860.0 nM 4.86
CHEMBL4082372 IC50 = 15390.0 nM 4.81
CHEMBL1910509 IC50 = 16450.0 nM 4.78
CHEMBL4072184 IC50 = 22850.0 nM 4.64
CHEMBL4101990 IC50 = 22960.0 nM 4.64
CHEMBL4065625 IC50 = 24410.0 nM 4.61
CHEMBL4099515 IC50 = 39970.0 nM 4.40
CHEMBL4075239 IC50 = 48500.0 nM 4.31