Assay Detail
Binding
CHEMBL4030175
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Inhibition of PARP1 (unknown origin) using activated DNA as substrate measured after 60 mins in presence of biotinylated NAD by colorimetric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.53 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4099515 | — | — | 1 | 6.13 |
| CHEMBL4075239 | — | — | 1 | 6.09 |
| CHEMBL4105580 | — | — | 1 | 5.87 |
| CHEMBL4063888 | — | — | 1 | 5.81 |
| CHEMBL4072184 | — | — | 1 | 5.51 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | — | 1 | 5.32 |
| CHEMBL4101990 | — | — | 1 | 5.32 |
| CHEMBL4090218 | — | — | 1 | 5.30 |
| CHEMBL4065625 | — | — | 1 | 5.11 |
| CHEMBL4069154 | — | — | 1 | 4.86 |
| CHEMBL1910509 | — | — | 1 | - |
| CHEMBL4082372 | — | — | 1 | - |
| CHEMBL4079898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4099515 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4075239 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4105580 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4063888 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4072184 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL4101990 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL4090218 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4065625 | — | IC50 | = | 7810.0 | nM | 5.11 |
| CHEMBL4069154 | — | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL1910509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4082372 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4079898 | — | IC50 | > | 100000.0 | nM | - |