Assay Detail
Binding
CHEMBL4030332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human RAGE cytoplasmic domain by tryptophan fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Advanced glycosylation end product-specific receptor (CHEMBL2176846) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 8.62 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101927 | — | — | 1 | 9.52 |
| CHEMBL4077165 | — | — | 1 | 9.00 |
| CHEMBL1477694 | — | — | 1 | 9.00 |
| CHEMBL4063929 | — | — | 1 | 8.70 |
| CHEMBL4072531 | — | — | 1 | 8.70 |
| CHEMBL4100986 | — | — | 1 | 8.52 |
| CHEMBL4075539 | — | — | 1 | 8.40 |
| CHEMBL1463447 | — | — | 1 | 8.22 |
| CHEMBL1547178 | — | — | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101927 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL4077165 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL1477694 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL4063929 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4072531 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4100986 | — | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL4075539 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL1463447 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL1547178 | — | Kd | = | 32.0 | nM | 7.50 |