Assay Detail
Binding
CHEMBL4030416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in HEK293 cells by patch clamp method
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.73 | 5.56 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321494 | — | — | 2 | 5.56 |
| CHEMBL432798 | — | — | 2 | 4.54 |
| CHEMBL4075428 | — | — | 1 | 4.08 |
| CHEMBL1773422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321494 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL432798 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL4075428 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL1773422 | — | IC50 | = | 213000.0 | nM | - |
| CHEMBL432798 | — | Inhibition | - | % | - | |
| CHEMBL321494 | — | Inhibition | - | % | - |