Assay Detail

CHEMBL4030424

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of PDE4 in human U937 cells assessed as [3H]cAMP hydrolysis

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.

Albrecht W, Unger A, Bauer SM, Laufer SA.
J Med Chem (2017) 60 : 5290 -5305
PubMed 28613871 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.20	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1773422	—	—	1	6.70
CHEMBL4075428	—	—	1	5.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1773422	—	IC50	=	200.0	nM	6.70
CHEMBL4075428	—	IC50	=	2000.0	nM	5.70