Assay Detail
Binding
CHEMBL4030909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BRPF3 (588 to 701 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bromodomain and PHD finger-containing protein 3 (CHEMBL3108644) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.82 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3752151 | — | — | 1 | 6.85 |
| CHEMBL4103077 | — | — | 1 | 6.72 |
| CHEMBL4102050 | — | — | 1 | 6.58 |
| CHEMBL4059962 | — | — | 1 | 6.55 |
| CHEMBL4087315 | — | — | 1 | 6.23 |
| CHEMBL4076056 | — | — | 1 | 6.00 |
| CHEMBL4102751 | — | — | 1 | 5.66 |
| CHEMBL4084805 | — | — | 1 | 5.66 |
| CHEMBL4064071 | — | — | 1 | 5.66 |
| CHEMBL4067917 | — | — | 1 | 5.34 |
| CHEMBL4065116 | — | — | 1 | 5.34 |
| CHEMBL4067436 | — | — | 1 | 5.12 |
| CHEMBL4105505 | — | — | 1 | 5.00 |
| CHEMBL4086558 | — | — | 1 | 4.80 |
| CHEMBL4059509 | — | — | 1 | - |
| CHEMBL4072276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3752151 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4103077 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4102050 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4059962 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4087315 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL4076056 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4102751 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4084805 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4064071 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4067917 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4065116 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4067436 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4105505 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4086558 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4059509 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4072276 | — | IC50 | > | 100000.0 | nM | - |