Assay Detail
Binding
CHEMBL4030910
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human BRD9 (130 to 259 residues) expressed in Escherichia coli BL21 after 1 hr by BROMOscan assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.86 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103077 | — | — | 1 | 6.77 |
| CHEMBL4102050 | — | — | 1 | 6.51 |
| CHEMBL3752151 | — | — | 1 | 6.28 |
| CHEMBL4076056 | — | — | 1 | 6.04 |
| CHEMBL4067436 | — | — | 1 | 5.66 |
| CHEMBL4102751 | — | — | 1 | 5.57 |
| CHEMBL4065116 | — | — | 1 | 5.03 |
| CHEMBL4072276 | — | — | 1 | 5.01 |
| CHEMBL4059509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103077 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4102050 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3752151 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4076056 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4067436 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4102751 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4065116 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4072276 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4059509 | — | IC50 | > | 100000.0 | nM | - |