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Assay Detail

CHEMBL4030927

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of BRPF1B (unknown origin) binding to histone H3.3 by nonoBRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peregrin (CHEMBL3132741)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
Igoe N, Bayle ED, Tallant C, Fedorov O, Meier JC, Savitsky P, Rogers C, Morias Y, Scholze S, Boyd H, Cunoosamy D, Andrews DM, Cheasty A, Brennan PE, Müller S, Knapp S, Fish PV.
J Med Chem (2017) 60 : 6998 -7011
PubMed 28714688 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.16 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3752151 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3752151 IC50 = 70.0 nM 7.16