Assay Detail
Binding
CHEMBL4031112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assay
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (CHEMBL3860) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural Biology-Inspired Discovery of Novel KRAS-PDEδ Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 7.83 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061005 | — | — | 3 | 9.22 |
| CHEMBL1387422 | — | — | 1 | 8.66 |
| CHEMBL4090695 | — | — | 1 | 8.64 |
| CHEMBL4061982 | — | — | 1 | 8.40 |
| CHEMBL4082888 | — | — | 1 | 8.40 |
| CHEMBL4090022 | — | — | 1 | 8.10 |
| CHEMBL4091313 | — | — | 1 | 8.05 |
| CHEMBL4092911 | — | — | 1 | 7.92 |
| CHEMBL4069561 | — | — | 1 | 7.82 |
| CHEMBL4072582 | — | — | 1 | 7.80 |
| CHEMBL4060010 | — | — | 1 | 7.66 |
| CHEMBL3286929 | — | — | 1 | 7.62 |
| CHEMBL4080394 | — | — | 1 | 7.48 |
| CHEMBL4073704 | — | — | 1 | 7.24 |
| CHEMBL4084687 | — | — | 1 | 7.12 |
| CHEMBL4083592 | — | — | 1 | 6.64 |
| CHEMBL4098417 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061005 | — | Kd | = | 0.6 | nM | 9.22 |
| CHEMBL4061005 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL1387422 | — | Kd | = | 2.2 | nM | 8.66 |
| CHEMBL4090695 | — | Kd | = | 2.3 | nM | 8.64 |
| CHEMBL4061982 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4082888 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL4090022 | — | Kd | = | 8.0 | nM | 8.10 |
| CHEMBL4091313 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL4092911 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL4069561 | — | Kd | = | 15.0 | nM | 7.82 |
| CHEMBL4072582 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL4060010 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL3286929 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL4080394 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL4061005 | — | Kd | = | 37.0 | nM | 7.43 |
| CHEMBL4073704 | — | Kd | = | 57.8 | nM | 7.24 |
| CHEMBL4084687 | — | Kd | = | 76.0 | nM | 7.12 |
| CHEMBL4083592 | — | Kd | = | 227.0 | nM | 6.64 |
| CHEMBL4098417 | — | Kd | = | 1119.0 | nM | 5.95 |