Assay Detail
Functional
CHEMBL4031138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against Toxoplasma gondii RH genotype 1 2F clone expressing bacterial beta-galactosidase infected in human HFF cells preincubated for 4 hrs followed by compound washout measured after 72 hrs by chlorophenol red-beta-D-galactopyranoside based spectrophotometry
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.11 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094646 | — | — | 1 | 6.79 |
| CHEMBL2324597 | — | — | 1 | 6.78 |
| CHEMBL4086945 | — | — | 1 | 6.72 |
| CHEMBL4090858 | — | — | 1 | 6.62 |
| CHEMBL4102392 | — | — | 1 | 6.61 |
| CHEMBL4069991 | — | — | 1 | 6.58 |
| CHEMBL4078124 | — | — | 1 | 6.52 |
| CHEMBL4074754 | — | — | 1 | 6.43 |
| CHEMBL4093769 | — | — | 1 | 6.36 |
| CHEMBL4087915 | — | — | 1 | 6.30 |
| CHEMBL4097112 | — | — | 1 | 6.27 |
| CHEMBL2324593 | — | — | 1 | 6.21 |
| CHEMBL4069866 | — | — | 1 | 6.14 |
| CHEMBL4096137 | — | — | 1 | 6.10 |
| CHEMBL4088534 | — | — | 1 | 6.00 |
| CHEMBL4098707 | — | — | 1 | 6.00 |
| CHEMBL4065764 | — | — | 1 | 5.95 |
| CHEMBL4060191 | — | — | 1 | 5.74 |
| CHEMBL4090973 | — | — | 1 | 5.74 |
| CHEMBL4065140 | — | — | 1 | 5.72 |
| CHEMBL4068845 | — | — | 1 | 5.58 |
| CHEMBL4095218 | — | — | 1 | 5.53 |
| CHEMBL4098582 | — | — | 1 | 5.46 |
| CHEMBL4073069 | — | — | 1 | 5.39 |
| CHEMBL4080552 | — | — | 1 | 5.22 |
| CHEMBL4067196 | — | — | 1 | - |
| CHEMBL4088414 | — | — | 1 | - |
| CHEMBL4080665 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094646 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL2324597 | — | EC50 | = | 167.0 | nM | 6.78 |
| CHEMBL4086945 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4090858 | — | EC50 | = | 242.0 | nM | 6.62 |
| CHEMBL4102392 | — | EC50 | = | 246.0 | nM | 6.61 |
| CHEMBL4069991 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL4078124 | — | EC50 | = | 305.0 | nM | 6.52 |
| CHEMBL4074754 | — | EC50 | = | 367.0 | nM | 6.43 |
| CHEMBL4093769 | — | EC50 | = | 437.0 | nM | 6.36 |
| CHEMBL4087915 | — | EC50 | = | 497.0 | nM | 6.30 |
| CHEMBL4097112 | — | EC50 | = | 537.0 | nM | 6.27 |
| CHEMBL2324593 | — | EC50 | = | 613.0 | nM | 6.21 |
| CHEMBL4069866 | — | EC50 | = | 729.0 | nM | 6.14 |
| CHEMBL4096137 | — | EC50 | = | 799.0 | nM | 6.10 |
| CHEMBL4088534 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4098707 | — | EC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL4065764 | — | EC50 | = | 1131.0 | nM | 5.95 |
| CHEMBL4060191 | — | EC50 | = | 1821.0 | nM | 5.74 |
| CHEMBL4090973 | — | EC50 | = | 1803.0 | nM | 5.74 |
| CHEMBL4065140 | — | EC50 | = | 1897.0 | nM | 5.72 |
| CHEMBL4068845 | — | EC50 | = | 2653.0 | nM | 5.58 |
| CHEMBL4095218 | — | EC50 | = | 2979.0 | nM | 5.53 |
| CHEMBL4098582 | — | EC50 | = | 3476.0 | nM | 5.46 |
| CHEMBL4073069 | — | EC50 | = | 4091.0 | nM | 5.39 |
| CHEMBL4080552 | — | EC50 | = | 5976.0 | nM | 5.22 |
| CHEMBL4067196 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4088414 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4080665 | — | EC50 | > | 10000.0 | nM | - |