Assay Detail
Functional
CHEMBL4031329
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.04 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060201 | — | — | 1 | 6.10 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.92 |
| CHEMBL4060602 | — | — | 1 | 5.24 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.98 |
| CHEMBL4069283 | — | — | 1 | 4.89 |
| CHEMBL4070306 | — | — | 1 | 4.89 |
| CHEMBL4059703 | — | — | 1 | 4.88 |
| CHEMBL4088824 | — | — | 1 | 4.76 |
| CHEMBL4098975 | — | — | 1 | 4.59 |
| CHEMBL4091233 | — | — | 1 | 4.16 |
| CHEMBL4089113 | — | — | 1 | - |
| CHEMBL4084049 | — | — | 1 | - |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060201 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4060602 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4069283 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4070306 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4059703 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4088824 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4098975 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL4091233 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4089113 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4084049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1789941 | RUXOLITINIB | IC50 | > | 10000.0 | nM | - |