Assay Detail
Binding
CHEMBL4031374
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Inhibition of MMP10 (unknown origin) assessed using (5-FAM/QX) FRET peptide as substrate by fluorescence assay
35
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.21 | 7.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071820 | — | — | 2 | 7.53 |
| CHEMBL4080183 | — | — | 2 | 6.96 |
| CHEMBL4098213 | — | — | 2 | 6.88 |
| CHEMBL4079271 | — | — | 2 | 6.85 |
| CHEMBL4097812 | — | — | 2 | 6.61 |
| CHEMBL4105625 | — | — | 2 | 6.46 |
| CHEMBL3337894 | T-26c | — | 2 | 6.45 |
| CHEMBL4059777 | — | — | 2 | 6.36 |
| CHEMBL4101280 | — | — | 2 | 6.30 |
| CHEMBL4068434 | — | — | 2 | 6.28 |
| CHEMBL4063194 | — | — | 2 | 6.20 |
| CHEMBL4081325 | — | — | 2 | 6.15 |
| CHEMBL4100290 | — | — | 2 | 6.12 |
| CHEMBL4091076 | — | — | 2 | 5.92 |
| CHEMBL4088055 | — | — | 2 | 5.77 |
| CHEMBL4062094 | — | — | 2 | 5.69 |
| CHEMBL4095780 | — | — | 2 | 5.13 |
| CHEMBL3814018 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071820 | — | IC50 | = | 29.51 | nM | 7.53 |
| CHEMBL4071820 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4080183 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4080183 | — | IC50 | = | 112.2 | nM | 6.95 |
| CHEMBL4098213 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4098213 | — | IC50 | = | 141.25 | nM | 6.85 |
| CHEMBL4079271 | — | IC50 | = | 141.25 | nM | 6.85 |
| CHEMBL4079271 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4097812 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4105625 | — | IC50 | = | 347.0 | nM | 6.46 |
| CHEMBL3337894 | T-26c | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL4105625 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3337894 | T-26c | IC50 | = | 407.38 | nM | 6.39 |
| CHEMBL4059777 | — | IC50 | = | 436.52 | nM | 6.36 |
| CHEMBL4059777 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL4101280 | — | IC50 | = | 506.0 | nM | 6.30 |
| CHEMBL4068434 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL4101280 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL4097812 | — | IC50 | = | 588.84 | nM | 6.23 |
| CHEMBL4063194 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL4068434 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL4081325 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL4100290 | — | IC50 | = | 751.0 | nM | 6.12 |
| CHEMBL4063194 | — | IC50 | = | 831.76 | nM | 6.08 |
| CHEMBL4081325 | — | IC50 | = | 831.76 | nM | 6.08 |
| CHEMBL4100290 | — | IC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL4091076 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL4088055 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL4088055 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4062094 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4062094 | — | IC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL4095780 | — | IC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL3814018 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4095780 | — | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL4091076 | — | IC50 | = | 18197.01 | nM | 4.74 |