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Assay Detail

CHEMBL4031375

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Binding
Inhibition of C-terminal tagged human recombinant MMP13 catalytic domain expressed in Escherichia coli using (5-FAM/QX) FRET peptide as substrate by fluorescence assay
ChEMBL ↗
35
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Collagenase 3 (CHEMBL280) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor.
Senn N, Ott M, Lanz J, Riedl R.
J Med Chem (2017) 60 : 9585 -9598
PubMed 28953404 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 7.43 9.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3337894 T-26c — 2 9.72
CHEMBL4071820 — — 2 8.30
CHEMBL3814018 — — 1 8.22
CHEMBL4080183 — — 2 7.93
CHEMBL4081325 — — 2 7.85
CHEMBL4098213 — — 2 7.68
CHEMBL4079271 — — 2 7.60
CHEMBL4059777 — — 2 7.50
CHEMBL4068434 — — 2 7.46
CHEMBL4088055 — — 2 7.44
CHEMBL4105625 — — 2 7.24
CHEMBL4063194 — — 2 7.07
CHEMBL4097812 — — 2 7.05
CHEMBL4091076 — — 2 6.96
CHEMBL4101280 — — 2 6.89
CHEMBL4100290 — — 2 6.83
CHEMBL4062094 — — 2 6.76
CHEMBL4095780 — — 2 6.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3337894 T-26c IC50 = 0.19 nM 9.72
CHEMBL3337894 T-26c IC50 = 0.2754 nM 9.56
CHEMBL4071820 — IC50 = 5.0 nM 8.30
CHEMBL4071820 — IC50 = 5.495 nM 8.26
CHEMBL3814018 — IC50 = 6.0 nM 8.22
CHEMBL4080183 — IC50 = 11.75 nM 7.93
CHEMBL4081325 — IC50 = 14.0 nM 7.85
CHEMBL4080183 — IC50 = 14.0 nM 7.85
CHEMBL4081325 — IC50 = 15.14 nM 7.82
CHEMBL4098213 — IC50 = 20.89 nM 7.68
CHEMBL4079271 — IC50 = 25.0 nM 7.60
CHEMBL4098213 — IC50 = 26.0 nM 7.58
CHEMBL4059777 — IC50 = 32.0 nM 7.50
CHEMBL4059777 — IC50 = 34.67 nM 7.46
CHEMBL4068434 — IC50 = 35.0 nM 7.46
CHEMBL4079271 — IC50 = 34.67 nM 7.46
CHEMBL4088055 — IC50 = 36.31 nM 7.44
CHEMBL4068434 — IC50 = 40.74 nM 7.39
CHEMBL4105625 — IC50 = 58.0 nM 7.24
CHEMBL4088055 — IC50 = 66.0 nM 7.18
CHEMBL4105625 — IC50 = 72.44 nM 7.14
CHEMBL4063194 — IC50 = 86.0 nM 7.07
CHEMBL4097812 — IC50 = 89.0 nM 7.05
CHEMBL4091076 — IC50 = 111.0 nM 6.96
CHEMBL4097812 — IC50 = 109.65 nM 6.96
CHEMBL4063194 — IC50 = 112.2 nM 6.95
CHEMBL4101280 — IC50 = 128.0 nM 6.89
CHEMBL4100290 — IC50 = 149.0 nM 6.83
CHEMBL4101280 — IC50 = 158.49 nM 6.80
CHEMBL4091076 — IC50 = 162.18 nM 6.79
CHEMBL4062094 — IC50 = 175.0 nM 6.76
CHEMBL4100290 — IC50 = 194.98 nM 6.71
CHEMBL4062094 — IC50 = 218.78 nM 6.66
CHEMBL4095780 — IC50 = 258.0 nM 6.59
CHEMBL4095780 — IC50 = 323.59 nM 6.49