Assay Detail
Binding
CHEMBL4031608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Substrate activity at PTS in CHO cells assessed as reduction in cell viability after 48 hrs in presence of aminoguanidine by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Bioevaluation of Macrocycle-Polyamine Conjugates as Cell Migration Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.60 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074949 | — | — | 1 | 5.71 |
| CHEMBL4077239 | — | — | 1 | 5.62 |
| CHEMBL4077417 | — | — | 1 | 5.61 |
| CHEMBL4065836 | — | — | 1 | 5.60 |
| CHEMBL4092941 | — | — | 1 | 5.58 |
| CHEMBL4065277 | — | — | 1 | 5.55 |
| CHEMBL4093452 | — | — | 1 | 5.54 |
| CHEMBL4095381 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074949 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4077239 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4077417 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4065836 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL4092941 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL4065277 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4093452 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4095381 | — | IC50 | > | 100000.0 | nM | - |