Assay Detail
Functional
CHEMBL4031611
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Antiproliferative activity against human L3.6p1 cells after 48 hrs in presence of amine oxidase inhibitor aminoguanidine by MTS assay
16
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | L3.6p1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and Bioevaluation of Macrocycle-Polyamine Conjugates as Cell Migration Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.26 | 6.00 |
| IC5 | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093452 | — | — | 2 | 6.00 |
| CHEMBL4077417 | — | — | 2 | 5.90 |
| CHEMBL4092941 | — | — | 2 | 5.84 |
| CHEMBL4077239 | — | — | 2 | 5.79 |
| CHEMBL4065836 | — | — | 2 | 5.48 |
| CHEMBL4074949 | — | — | 2 | 4.62 |
| CHEMBL4095381 | — | — | 2 | 4.38 |
| CHEMBL4103133 | — | — | 2 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093452 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4077417 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4092941 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4077239 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4065836 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL4074949 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4095381 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4103133 | — | IC50 | = | 89400.0 | nM | 4.05 |
| CHEMBL4093452 | — | IC5 | = | 0.6 | uM | - |
| CHEMBL4065836 | — | IC5 | = | 1.64 | uM | - |
| CHEMBL4092941 | — | IC5 | = | 0.6 | uM | - |
| CHEMBL4077417 | — | IC5 | = | 0.6 | uM | - |
| CHEMBL4077239 | — | IC5 | = | 0.92 | uM | - |
| CHEMBL4095381 | — | IC5 | = | 8.4 | uM | - |
| CHEMBL4074949 | — | IC5 | = | 4.15 | uM | - |
| CHEMBL4103133 | — | IC5 | = | 80.0 | uM | - |