Assay Detail
Binding
CHEMBL4031660
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Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.41 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068781 | — | — | 1 | 5.97 |
| CHEMBL4080721 | — | — | 1 | 5.96 |
| CHEMBL4091027 | — | — | 1 | 5.96 |
| CHEMBL4074947 | — | — | 1 | 5.88 |
| CHEMBL4098767 | — | — | 1 | 5.87 |
| CHEMBL4073085 | — | — | 1 | 5.82 |
| CHEMBL4087903 | — | — | 1 | 5.77 |
| CHEMBL4065526 | — | — | 1 | 5.72 |
| CHEMBL4099949 | — | — | 1 | 5.54 |
| CHEMBL4074694 | — | — | 1 | 5.34 |
| CHEMBL4086789 | — | — | 1 | 5.27 |
| CHEMBL4096306 | — | — | 1 | 5.23 |
| CHEMBL4105436 | — | — | 1 | 5.05 |
| CHEMBL4095380 | — | — | 1 | 4.96 |
| CHEMBL4069043 | — | — | 1 | 4.57 |
| CHEMBL4068233 | — | — | 1 | 4.56 |
| CHEMBL4095604 | — | — | 1 | 4.54 |
| CHEMBL4103353 | — | — | 1 | - |
| CHEMBL4079103 | — | — | 1 | - |
| CHEMBL4059591 | — | — | 1 | - |
| CHEMBL4060357 | — | — | 1 | - |
| CHEMBL4087563 | — | — | 1 | - |
| CHEMBL4067849 | — | — | 1 | - |
| CHEMBL4085170 | — | — | 1 | - |
| CHEMBL4078740 | — | — | 1 | - |
| CHEMBL4089556 | — | — | 1 | - |
| CHEMBL4086585 | — | — | 1 | - |
| CHEMBL4076058 | — | — | 1 | - |
| CHEMBL4073732 | — | — | 1 | - |
| CHEMBL4090211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068781 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4080721 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4091027 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4074947 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4098767 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL4073085 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL4087903 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4065526 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL4099949 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4074694 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4086789 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4096306 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL4105436 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL4095380 | — | IC50 | = | 10980.0 | nM | 4.96 |
| CHEMBL4069043 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL4068233 | — | IC50 | = | 27470.0 | nM | 4.56 |
| CHEMBL4095604 | — | IC50 | = | 29020.0 | nM | 4.54 |
| CHEMBL4103353 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4079103 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4059591 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4060357 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4087563 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4067849 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4085170 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4078740 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4089556 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4086585 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4076058 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4073732 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4090211 | — | IC50 | > | 40000.0 | nM | - |