Assay Detail
Binding
CHEMBL4031661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by HRE dual-luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.98 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178407 | — | — | 1 | 6.13 |
| CHEMBL4068781 | — | — | 1 | 5.97 |
| CHEMBL4091027 | — | — | 1 | 5.85 |
| CHEMBL4068233 | — | — | 1 | - |
| CHEMBL4085170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178407 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4068781 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4091027 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4068233 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4085170 | — | IC50 | > | 40000.0 | nM | - |