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Assay Detail

CHEMBL4031739

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Functional
Cytotoxicity against human CAL51 cells assessed as reduction in cell viability after 3 days by CellTiter-Glo assay
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CAL-51
Confidence 1 — Organism
Curated By Autocuration

Target

CAL-51 (CHEMBL1075411) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, Katz J, Tang Y, Chen M, Moghaddam MF, Bahmanyar S, Pagarigan B, Delker S, LeBrun L, Chamberlain PP, Calabrese A, Canan SS, Leftheris K, Zhu D, Boylan JF.
J Med Chem (2017) 60 : 8989 -9002
PubMed 28991472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 7.16 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4078291 — — 1 8.10
CHEMBL4086674 — — 1 8.10
CHEMBL4088669 — — 1 8.10
CHEMBL4060730 — — 1 8.05
CHEMBL4093026 — — 1 7.96
CHEMBL4068490 — — 1 7.89
CHEMBL4090966 — — 1 7.82
CHEMBL4086004 — — 1 7.77
CHEMBL4098047 — — 1 7.77
CHEMBL4097084 — — 1 7.77
CHEMBL4063065 — — 1 7.70
CHEMBL4078595 — — 1 7.52
CHEMBL4095765 — — 1 7.51
CHEMBL4066568 — — 1 7.43
CHEMBL4066315 — — 1 7.40
CHEMBL4061354 — — 1 7.33
CHEMBL4075857 — — 1 7.25
CHEMBL4062218 — — 1 7.22
CHEMBL4080975 — — 1 7.21
CHEMBL4060209 — — 1 7.21
CHEMBL4061555 — — 1 7.17
CHEMBL4063632 — — 1 7.15
CHEMBL4099734 — — 1 7.11
CHEMBL4066617 — — 1 7.11
CHEMBL4086597 — — 1 7.10
CHEMBL4076181 — — 1 7.05
CHEMBL4065773 — — 1 6.96
CHEMBL4091034 — — 1 6.95
CHEMBL4074116 — — 1 6.91
CHEMBL4071138 — — 1 6.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4078291 — IC50 = 8.0 nM 8.10
CHEMBL4088669 — IC50 = 8.0 nM 8.10
CHEMBL4086674 — IC50 = 8.0 nM 8.10
CHEMBL4060730 — IC50 = 9.0 nM 8.05
CHEMBL4093026 — IC50 = 11.0 nM 7.96
CHEMBL4068490 — IC50 = 13.0 nM 7.89
CHEMBL4090966 — IC50 = 15.0 nM 7.82
CHEMBL4086004 — IC50 = 17.0 nM 7.77
CHEMBL4098047 — IC50 = 17.0 nM 7.77
CHEMBL4097084 — IC50 = 17.0 nM 7.77
CHEMBL4063065 — IC50 = 20.0 nM 7.70
CHEMBL4078595 — IC50 = 30.0 nM 7.52
CHEMBL4095765 — IC50 = 31.0 nM 7.51
CHEMBL4066568 — IC50 = 37.0 nM 7.43
CHEMBL4066315 — IC50 = 40.0 nM 7.40
CHEMBL4061354 — IC50 = 47.0 nM 7.33
CHEMBL4075857 — IC50 = 56.0 nM 7.25
CHEMBL4062218 — IC50 = 60.0 nM 7.22
CHEMBL4060209 — IC50 = 61.0 nM 7.21
CHEMBL4080975 — IC50 = 61.0 nM 7.21
CHEMBL4061555 — IC50 = 67.0 nM 7.17
CHEMBL4063632 — IC50 = 71.0 nM 7.15
CHEMBL4099734 — IC50 = 77.0 nM 7.11
CHEMBL4066617 — IC50 = 77.0 nM 7.11
CHEMBL4086597 — IC50 = 79.0 nM 7.10
CHEMBL4076181 — IC50 = 89.0 nM 7.05
CHEMBL4065773 — IC50 = 109.0 nM 6.96
CHEMBL4091034 — IC50 = 113.0 nM 6.95
CHEMBL4074116 — IC50 = 123.0 nM 6.91
CHEMBL4071138 — IC50 = 147.0 nM 6.83
CHEMBL4061401 — IC50 = 338.0 nM 6.47
CHEMBL4092644 — IC50 = 349.0 nM 6.46
CHEMBL4077306 — IC50 = 351.0 nM 6.46
CHEMBL4063994 — IC50 = 460.0 nM 6.34
CHEMBL4066729 — IC50 = 491.0 nM 6.31
CHEMBL4090356 — IC50 = 496.0 nM 6.30
CHEMBL4080238 — IC50 = 642.0 nM 6.19
CHEMBL4064411 — IC50 = 771.0 nM 6.11
CHEMBL4068276 — IC50 = 10000.0 nM 5.00