Assay Detail
Binding
CHEMBL4032001
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Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.20 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103328 | — | — | 1 | 9.07 |
| CHEMBL607351 | — | — | 1 | 8.90 |
| CHEMBL4065490 | — | — | 1 | 8.40 |
| CHEMBL4088589 | — | — | 1 | 8.10 |
| CHEMBL607405 | — | — | 1 | 8.00 |
| CHEMBL326684 | — | — | 1 | 7.82 |
| CHEMBL4074110 | — | — | 1 | 7.67 |
| CHEMBL963 | OXYMORPHONE | 4.0 | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103328 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL607351 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL4065490 | — | Ki | = | 3.99 | nM | 8.40 |
| CHEMBL4088589 | — | Ki | = | 7.92 | nM | 8.10 |
| CHEMBL607405 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL326684 | — | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL4074110 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL963 | OXYMORPHONE | Ki | = | 25.3 | nM | 7.60 |