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Assay Detail

CHEMBL4032322

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A673 cells after 48 hrs by CellTiter-Glo assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A673
Confidence 1 — Organism
Curated By Autocuration

Target

A673 (CHEMBL614517)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ.
J Med Chem (2017) 60 : 9184 -9204
PubMed 29120638 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.04 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4065858 1 5.58
CHEMBL4081890 1 5.54
CHEMBL4100845 1 4.86
CHEMBL4059985 1 4.61
CHEMBL4082867 1 4.59
CHEMBL3335794 1 -
CHEMBL4076973 1 -
CHEMBL4084774 1 -
CHEMBL4063125 1 -
CHEMBL4099443 1 -
CHEMBL4069796 1 -
CHEMBL4090794 1 -
CHEMBL4080497 1 -
CHEMBL2059811 1 -
CHEMBL4076958 1 -
CHEMBL4066429 1 -
CHEMBL4092360 1 -
CHEMBL4075666 1 -
CHEMBL4101800 1 -
CHEMBL4090677 1 -
CHEMBL4076027 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4065858 IC50 = 2630.0 nM 5.58
CHEMBL4081890 IC50 = 2900.0 nM 5.54
CHEMBL4100845 IC50 = 13900.0 nM 4.86
CHEMBL4059985 IC50 = 24800.0 nM 4.61
CHEMBL4082867 IC50 = 25800.0 nM 4.59
CHEMBL3335794 IC50 > 57000.0 nM -
CHEMBL4076973 IC50 > 57000.0 nM -
CHEMBL4084774 IC50 > 57000.0 nM -
CHEMBL4063125 IC50 > 57000.0 nM -
CHEMBL4099443 IC50 > 57000.0 nM -
CHEMBL4069796 IC50 > 57000.0 nM -
CHEMBL4090794 IC50 > 57000.0 nM -
CHEMBL4080497 IC50 > 57000.0 nM -
CHEMBL2059811 IC50 > 57000.0 nM -
CHEMBL4076958 IC50 > 57000.0 nM -
CHEMBL4066429 IC50 > 57000.0 nM -
CHEMBL4092360 IC50 > 57000.0 nM -
CHEMBL4075666 IC50 > 57000.0 nM -
CHEMBL4101800 IC50 > 57000.0 nM -
CHEMBL4090677 IC50 > 57000.0 nM -
CHEMBL4076027 IC50 > 57000.0 nM -