Assay Detail
Binding
CHEMBL4032328
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Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.05 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4059985 | — | — | 1 | 7.16 |
| CHEMBL4081890 | — | — | 1 | 6.77 |
| CHEMBL4100845 | — | — | 1 | 6.60 |
| CHEMBL4065858 | — | — | 1 | 5.90 |
| CHEMBL2059811 | — | — | 1 | 5.80 |
| CHEMBL4080497 | — | — | 1 | 5.59 |
| CHEMBL4076973 | — | — | 1 | 5.45 |
| CHEMBL3335794 | — | — | 1 | 5.09 |
| CHEMBL1479261 | — | — | 1 | - |
| CHEMBL4101800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4059985 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4081890 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4100845 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4065858 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL2059811 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4080497 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL4076973 | — | EC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL3335794 | — | EC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL1479261 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4101800 | — | EC50 | > | 100000.0 | nM | - |