Assay Detail
Binding
CHEMBL4032330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescence assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 6.38 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4059985 | — | — | 1 | 8.05 |
| CHEMBL4090677 | — | — | 1 | 7.72 |
| CHEMBL4100845 | — | — | 1 | 7.57 |
| CHEMBL4081890 | — | — | 1 | 7.50 |
| CHEMBL3335794 | — | — | 1 | 7.42 |
| CHEMBL4080497 | — | — | 1 | 7.42 |
| CHEMBL4069726 | — | — | 1 | 7.38 |
| CHEMBL4101800 | — | — | 1 | 7.28 |
| CHEMBL4076027 | — | — | 1 | 7.24 |
| CHEMBL4075666 | — | — | 1 | 7.19 |
| CHEMBL4062709 | — | — | 1 | 7.19 |
| CHEMBL4076958 | — | — | 1 | 7.04 |
| CHEMBL4069796 | — | — | 1 | 7.02 |
| CHEMBL4082867 | — | — | 1 | 6.96 |
| CHEMBL4067976 | — | — | 1 | 6.94 |
| CHEMBL4098516 | — | — | 1 | 6.91 |
| CHEMBL4095368 | — | — | 1 | 6.86 |
| CHEMBL4090794 | — | — | 1 | 6.75 |
| CHEMBL4063125 | — | — | 1 | 6.46 |
| CHEMBL4066429 | — | — | 1 | 6.46 |
| CHEMBL4065858 | — | — | 1 | 6.37 |
| CHEMBL4076973 | — | — | 1 | 6.17 |
| CHEMBL4099443 | — | — | 1 | 6.12 |
| CHEMBL2059811 | — | — | 1 | 5.87 |
| CHEMBL4084774 | — | — | 1 | 5.62 |
| CHEMBL4092360 | — | — | 1 | 5.21 |
| CHEMBL4079793 | — | — | 1 | 4.76 |
| CHEMBL4079457 | — | — | 1 | 4.59 |
| CHEMBL4077586 | — | — | 1 | 4.56 |
| CHEMBL4098402 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4059985 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4090677 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4100845 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4081890 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3335794 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4080497 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4069726 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4101800 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4076027 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4075666 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4062709 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4076958 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4069796 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4082867 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4067976 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4098516 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL4095368 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4090794 | — | IC50 | = | 176.0 | nM | 6.75 |
| CHEMBL4063125 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL4066429 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL4065858 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL4076973 | — | IC50 | = | 672.0 | nM | 6.17 |
| CHEMBL4099443 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL2059811 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4084774 | — | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL4092360 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL4079793 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4079457 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL4077586 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL4098402 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL1479261 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4080650 | — | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL4096076 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4081640 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4073737 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4076264 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4066686 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4062653 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4059909 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4070504 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4094023 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4073369 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4097383 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL2442491 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4060749 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4089051 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4097495 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4071354 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4090108 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL4097822 | — | IC50 | > | 57000.0 | nM | - |