Assay Detail
Functional
CHEMBL4032336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MIAPaCa2 cells assessed as long term cell growth inhibition measured every 4 hrs for 120 hrs by incucyte zoom live cell analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.63 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081890 | — | — | 1 | 5.92 |
| CHEMBL3335794 | — | — | 1 | 5.86 |
| CHEMBL4100845 | — | — | 1 | 5.10 |
| CHEMBL2059811 | — | — | 1 | - |
| CHEMBL4080497 | — | — | 1 | - |
| CHEMBL4101800 | — | — | 1 | - |
| CHEMBL4059985 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081890 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3335794 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4100845 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2059811 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4080497 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4101800 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4059985 | — | IC50 | > | 20000.0 | nM | - |