Assay Detail
ADMET
CHEMBL4032997
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Inhibition of GST-tagged recombinant human JAK2 catalytic domain expressed in baculovirus expression system using LCB-EQEDEPEGDYFEWLW-NH2 as substrate preincubated for 30 mins followed by ATP addition measured after 120 mins by HTRF assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.56 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089118 | — | — | 1 | 9.33 |
| CHEMBL4078799 | — | — | 1 | 9.30 |
| CHEMBL4096821 | — | — | 1 | 9.15 |
| CHEMBL4102140 | — | — | 1 | 9.10 |
| CHEMBL4061128 | — | — | 1 | 8.92 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.85 |
| CHEMBL4089234 | — | — | 1 | 8.82 |
| CHEMBL4077886 | — | — | 1 | 8.72 |
| CHEMBL4104623 | — | — | 1 | 8.70 |
| CHEMBL4066906 | — | — | 1 | 8.70 |
| CHEMBL4085737 | — | — | 1 | 8.57 |
| CHEMBL4067915 | — | — | 1 | 8.55 |
| CHEMBL4100288 | — | — | 1 | 8.52 |
| CHEMBL4072848 | — | — | 1 | 8.49 |
| CHEMBL4092626 | — | — | 1 | 8.47 |
| CHEMBL4071005 | — | — | 1 | 8.41 |
| CHEMBL4064171 | — | — | 1 | 8.30 |
| CHEMBL4066193 | ATINVICITINIB | 2.0 | 1 | 8.22 |
| CHEMBL4079092 | — | — | 1 | 8.15 |
| CHEMBL4076473 | — | — | 1 | 8.15 |
| CHEMBL4088262 | — | — | 1 | 8.00 |
| CHEMBL4098999 | — | — | 1 | 7.80 |
| CHEMBL3703085 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089118 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4078799 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4096821 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4102140 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4061128 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4089234 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4077886 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4104623 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4066906 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4085737 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4067915 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4100288 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4072848 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4092626 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4071005 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4064171 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4066193 | ATINVICITINIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4079092 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4076473 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4088262 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4098999 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3703085 | — | IC50 | = | 19.0 | nM | 7.72 |