Assay Detail
Binding
CHEMBL4033254
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human VEGFR2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Potent VEGFR-2 Inhibitors Exerting Significant Antiproliferative Activity against Cancer Cell Lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.89 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 9.70 |
| CHEMBL1289601 | LENVATINIB | 4.0 | 1 | 8.40 |
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 7.68 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.40 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.10 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1289926 | AXITINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1289601 | LENVATINIB | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL502835 | NINTEDANIB | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL535 | SUNITINIB | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 90.0 | nM | 7.05 |