Assay Detail
Binding
CHEMBL4033369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to biotin-labeled human truncated PAK4 kinase domain by surface plasmon resonance assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PAK 4 (CHEMBL4482) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.18 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076708 | — | — | 1 | 8.22 |
| CHEMBL4064068 | — | — | 1 | 7.80 |
| CHEMBL4091048 | — | — | 1 | 7.37 |
| CHEMBL4093999 | — | — | 1 | 7.18 |
| CHEMBL4084054 | — | — | 1 | 6.81 |
| CHEMBL4093649 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076708 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL4064068 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL4091048 | — | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL4093999 | — | Kd | = | 66.0 | nM | 7.18 |
| CHEMBL4084054 | — | Kd | = | 156.0 | nM | 6.81 |
| CHEMBL4093649 | — | Kd | = | 1940.0 | nM | 5.71 |