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Assay Detail

CHEMBL4033802

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells incubated for 72 hrs by SRB assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity.
Ren Y, Chen WL, Lantvit DD, Sass EJ, Shriwas P, Ninh TN, Chai HB, Zhang X, Soejarto DD, Chen X, Lucas DM, Swanson SM, Burdette JE, Kinghorn AD.
J Nat Prod (2017) 80 : 648 -658
PubMed 27983842 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.65 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 9.10
CHEMBL400876 1 7.05
CHEMBL4100694 1 6.80
CHEMBL449686 STREBLOSIDE 1 6.77
CHEMBL4073120 1 6.44
CHEMBL1751 DIGOXIN 4.0 1 6.42
CHEMBL4099056 1 6.33
CHEMBL4073923 1 6.16
CHEMBL4081023 1 5.92
CHEMBL4065560 1 5.55
CHEMBL4086991 1 -
CHEMBL4078423 1 -
CHEMBL4096466 1 -
CHEMBL4060641 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 0.8 nM 9.10
CHEMBL400876 IC50 = 90.0 nM 7.05
CHEMBL4100694 IC50 = 160.0 nM 6.80
CHEMBL449686 STREBLOSIDE IC50 = 170.0 nM 6.77
CHEMBL4073120 IC50 = 360.0 nM 6.44
CHEMBL1751 DIGOXIN IC50 = 380.0 nM 6.42
CHEMBL4099056 IC50 = 470.0 nM 6.33
CHEMBL4073923 IC50 = 690.0 nM 6.16
CHEMBL4081023 IC50 = 1200.0 nM 5.92
CHEMBL4065560 IC50 = 2800.0 nM 5.55
CHEMBL4086991 IC50 > 20000.0 nM -
CHEMBL4078423 IC50 > 20000.0 nM -
CHEMBL4096466 IC50 > 20000.0 nM -
CHEMBL4060641 IC50 > 20000.0 nM -