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Assay Detail

CHEMBL4033952

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Autophagy antagonizes apoptosis induced by flavan enantiomers from Daphne giraldii in hepatic carcinoma cells in vitro.
Sun Q, Yao GD, Song XY, Qi XL, Xi YF, Li LZ, Huang XX, Song SJ.
Eur J Med Chem (2017) 133 : 1 -10
PubMed 28371676 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.23 4.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185 FLUOROURACIL 4.0 1 4.42
CHEMBL2235440 1 4.03
CHEMBL4066416 1 -
CHEMBL465371 KAZINOL B 1 -
CHEMBL1084746 KAZINOL U 1 -
CHEMBL4084180 1 -
CHEMBL4068141 1 -
CHEMBL4103098 1 -
CHEMBL4086676 1 -
CHEMBL4065236 1 -
CHEMBL4068307 1 -
CHEMBL4089488 1 -
CHEMBL4060586 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185 FLUOROURACIL IC50 = 38200.0 nM 4.42
CHEMBL2235440 IC50 = 92500.0 nM 4.03
CHEMBL4066416 IC50 > 100000.0 nM -
CHEMBL465371 KAZINOL B IC50 > 100000.0 nM -
CHEMBL1084746 KAZINOL U IC50 > 100000.0 nM -
CHEMBL4084180 IC50 > 100000.0 nM -
CHEMBL4068141 IC50 > 100000.0 nM -
CHEMBL4103098 IC50 > 100000.0 nM -
CHEMBL4086676 IC50 > 100000.0 nM -
CHEMBL4065236 IC50 > 100000.0 nM -
CHEMBL4068307 IC50 > 100000.0 nM -
CHEMBL4089488 IC50 > 100000.0 nM -
CHEMBL4060586 IC50 > 100000.0 nM -