Assay Detail
Functional
CHEMBL4034028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells after 48 hrs by CCK8 assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.60 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070828 | — | — | 1 | 5.92 |
| CHEMBL4097936 | — | — | 1 | 5.47 |
| CHEMBL4080686 | — | — | 1 | 5.38 |
| CHEMBL4077432 | — | — | 1 | 4.95 |
| CHEMBL388525 | — | — | 1 | 4.95 |
| CHEMBL4083007 | — | — | 1 | 4.89 |
| CHEMBL4061540 | — | — | 1 | 4.87 |
| CHEMBL4076096 | — | — | 1 | 4.68 |
| CHEMBL4102267 | — | — | 1 | 4.67 |
| CHEMBL4100990 | — | — | 1 | 4.64 |
| CHEMBL365234 | — | — | 1 | 4.63 |
| CHEMBL4066666 | — | — | 1 | 4.63 |
| CHEMBL4068958 | — | — | 1 | 4.55 |
| CHEMBL361025 | — | — | 1 | 4.51 |
| CHEMBL469039 | — | — | 1 | 4.50 |
| CHEMBL4080350 | — | — | 1 | 4.46 |
| CHEMBL4069638 | — | — | 1 | 4.38 |
| CHEMBL185788 | — | — | 1 | 4.38 |
| CHEMBL4072355 | — | — | 1 | 4.37 |
| CHEMBL187265 | — | — | 1 | 4.37 |
| CHEMBL4090652 | — | — | 1 | 4.36 |
| CHEMBL4063934 | — | — | 1 | 4.28 |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | 4.26 |
| CHEMBL4098374 | — | — | 1 | 4.08 |
| CHEMBL4060966 | — | — | 1 | 4.04 |
| CHEMBL3357570 | — | — | 1 | 4.03 |
| CHEMBL446323 | 3,4-DIHYDROXYXANTHONE | — | 1 | 4.03 |
| CHEMBL448874 | EUXANTHONE | — | 1 | - |
| CHEMBL4094195 | — | — | 1 | - |
| CHEMBL365640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070828 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4097936 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4080686 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4077432 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL388525 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4083007 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4061540 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4076096 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4102267 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL4100990 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL365234 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4066666 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4068958 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL361025 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL469039 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL4080350 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL185788 | — | IC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL4069638 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL4072355 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL187265 | — | IC50 | = | 43200.0 | nM | 4.37 |
| CHEMBL4090652 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL4063934 | — | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL71263 | VADIMEZAN | IC50 | = | 54400.0 | nM | 4.26 |
| CHEMBL4098374 | — | IC50 | = | 83400.0 | nM | 4.08 |
| CHEMBL4060966 | — | IC50 | = | 91300.0 | nM | 4.04 |
| CHEMBL3357570 | — | IC50 | = | 92400.0 | nM | 4.03 |
| CHEMBL446323 | 3,4-DIHYDROXYXANTHONE | IC50 | = | 93200.0 | nM | 4.03 |
| CHEMBL448874 | EUXANTHONE | IC50 | = | 128100.0 | nM | - |
| CHEMBL4094195 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL365640 | — | IC50 | = | 121100.0 | nM | - |
| CHEMBL4086438 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4077661 | — | IC50 | = | 103700.0 | nM | - |
| CHEMBL468353 | — | IC50 | = | 111900.0 | nM | - |
| CHEMBL4081403 | — | IC50 | > | 200000.0 | nM | - |