Assay Detail
Functional
CHEMBL4034032
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Synergistic antiproliferative activity against human MDA-MB-231 cells at compound to DMXAA mol ratio of 1:1 after 48 hrs by CCK8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of xanthone derivatives and studies on the inhibition against cancer cells growth and synergistic combinations of them.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.88 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097936 | — | — | 1 | 7.38 |
| CHEMBL4080686 | — | — | 1 | 5.58 |
| CHEMBL4070828 | — | — | 1 | 5.51 |
| CHEMBL4077432 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097936 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4080686 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL4070828 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4077432 | — | IC50 | = | 9130.0 | nM | 5.04 |