Assay Detail
Binding
CHEMBL4034152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length HIV RT-RNase H activity using 18-nucleotide 3'-fluorescein-labeled RNA/5'-dabsyl-labeled DNA hybrid as substrate
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.03 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085574 | — | — | 1 | 6.70 |
| CHEMBL4063160 | — | — | 1 | 6.70 |
| CHEMBL4089954 | — | — | 1 | 6.70 |
| CHEMBL4071684 | — | — | 1 | 6.70 |
| CHEMBL4068016 | — | — | 1 | 6.52 |
| CHEMBL4077477 | — | — | 1 | 6.22 |
| CHEMBL4100254 | — | — | 1 | 6.09 |
| CHEMBL4090239 | — | — | 1 | 6.08 |
| CHEMBL1928102 | — | — | 1 | 6.05 |
| CHEMBL4104588 | — | — | 1 | 6.00 |
| CHEMBL1928103 | — | — | 1 | 5.96 |
| CHEMBL1928107 | — | — | 1 | 5.96 |
| CHEMBL1928110 | — | — | 1 | 5.96 |
| CHEMBL1928097 | — | — | 1 | 5.92 |
| CHEMBL1928112 | — | — | 1 | 5.92 |
| CHEMBL4105411 | — | — | 1 | 5.89 |
| CHEMBL1928115 | — | — | 1 | 5.89 |
| CHEMBL4068900 | — | — | 1 | 5.85 |
| CHEMBL4077002 | — | — | 1 | 5.85 |
| CHEMBL1928105 | — | — | 1 | 5.85 |
| CHEMBL461036 | — | — | 1 | 5.85 |
| CHEMBL4089987 | — | — | 1 | 5.82 |
| CHEMBL4101076 | — | — | 1 | 5.80 |
| CHEMBL4070690 | — | — | 1 | 5.80 |
| CHEMBL1928108 | — | — | 1 | 5.77 |
| CHEMBL1928098 | — | — | 1 | 5.77 |
| CHEMBL1928111 | — | — | 1 | 5.75 |
| CHEMBL4075643 | — | — | 1 | 5.70 |
| CHEMBL1928099 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085574 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4063160 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4089954 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4071684 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4068016 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4077477 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4100254 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4090239 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL1928102 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4104588 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1928103 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1928107 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1928110 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1928097 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1928112 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4105411 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1928115 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4068900 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4077002 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1928105 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL461036 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4089987 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4101076 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4070690 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1928108 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1928098 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1928111 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4075643 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1928099 | — | IC50 | = | 2000.0 | nM | 5.70 |