Assay Detail
Binding
CHEMBL4034611
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Inhibition of HDAC1 (unknown origin) preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069152 | — | — | 1 | 8.40 |
| CHEMBL4078380 | — | — | 1 | 8.14 |
| CHEMBL4076931 | — | — | 1 | 8.11 |
| CHEMBL4102654 | — | — | 1 | 8.09 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.95 |
| CHEMBL4075984 | — | — | 1 | 7.95 |
| CHEMBL4093350 | — | — | 1 | 7.84 |
| CHEMBL4068870 | — | — | 1 | 7.72 |
| CHEMBL4069669 | — | — | 1 | 7.59 |
| CHEMBL4087230 | — | — | 1 | 7.46 |
| CHEMBL4067480 | — | — | 1 | 7.25 |
| CHEMBL4089964 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069152 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4078380 | — | IC50 | = | 7.18 | nM | 8.14 |
| CHEMBL4076931 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4102654 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 11.11 | nM | 7.95 |
| CHEMBL4075984 | — | IC50 | = | 11.27 | nM | 7.95 |
| CHEMBL4093350 | — | IC50 | = | 14.35 | nM | 7.84 |
| CHEMBL4068870 | — | IC50 | = | 19.21 | nM | 7.72 |
| CHEMBL4069669 | — | IC50 | = | 25.66 | nM | 7.59 |
| CHEMBL4087230 | — | IC50 | = | 34.58 | nM | 7.46 |
| CHEMBL4067480 | — | IC50 | = | 56.84 | nM | 7.25 |
| CHEMBL4089964 | — | IC50 | = | 72.27 | nM | 7.14 |