Assay Detail
Binding
CHEMBL4034612
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Inhibition of HDAC6 (unknown origin) preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.90 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076931 | — | — | 1 | 8.33 |
| CHEMBL4069152 | — | — | 1 | 8.28 |
| CHEMBL4078380 | — | — | 1 | 8.15 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.11 |
| CHEMBL4093350 | — | — | 1 | 8.08 |
| CHEMBL4102654 | — | — | 1 | 7.97 |
| CHEMBL4075984 | — | — | 1 | 7.93 |
| CHEMBL4068870 | — | — | 1 | 7.92 |
| CHEMBL4067480 | — | — | 1 | 7.76 |
| CHEMBL4069669 | — | — | 1 | 7.44 |
| CHEMBL4087230 | — | — | 1 | 7.40 |
| CHEMBL4089964 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076931 | — | IC50 | = | 4.68 | nM | 8.33 |
| CHEMBL4069152 | — | IC50 | = | 5.28 | nM | 8.28 |
| CHEMBL4078380 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 7.76 | nM | 8.11 |
| CHEMBL4093350 | — | IC50 | = | 8.35 | nM | 8.08 |
| CHEMBL4102654 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL4075984 | — | IC50 | = | 11.87 | nM | 7.93 |
| CHEMBL4068870 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4067480 | — | IC50 | = | 17.39 | nM | 7.76 |
| CHEMBL4069669 | — | IC50 | = | 35.94 | nM | 7.44 |
| CHEMBL4087230 | — | IC50 | = | 39.93 | nM | 7.40 |
| CHEMBL4089964 | — | IC50 | = | 41.43 | nM | 7.38 |