Assay Detail
Functional
CHEMBL4034613
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.41 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078380 | — | — | 1 | 5.95 |
| CHEMBL2336409 | — | — | 1 | 5.94 |
| CHEMBL4075984 | — | — | 1 | 5.75 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL4068870 | — | — | 1 | 5.56 |
| CHEMBL4067480 | — | — | 1 | 5.54 |
| CHEMBL4069152 | — | — | 1 | 5.50 |
| CHEMBL4087230 | — | — | 1 | 5.44 |
| CHEMBL4102654 | — | — | 1 | 5.29 |
| CHEMBL4089964 | — | — | 1 | 5.21 |
| CHEMBL4069669 | — | — | 1 | 5.15 |
| CHEMBL4093350 | — | — | 1 | 4.75 |
| CHEMBL4076931 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078380 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL2336409 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL4075984 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4068870 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4067480 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4069152 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4087230 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL4102654 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4089964 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL4069669 | — | IC50 | = | 7060.0 | nM | 5.15 |
| CHEMBL4093350 | — | IC50 | = | 17950.0 | nM | 4.75 |
| CHEMBL4076931 | — | IC50 | = | 31710.0 | nM | 4.50 |