Assay Detail
Functional
CHEMBL4034614
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Antiproliferative activity against human U937 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.74 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068870 | — | — | 1 | 6.72 |
| CHEMBL4078380 | — | — | 1 | 6.28 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.27 |
| CHEMBL4087230 | — | — | 1 | 5.97 |
| CHEMBL4067480 | — | — | 1 | 5.97 |
| CHEMBL4069152 | — | — | 1 | 5.90 |
| CHEMBL2336409 | — | — | 1 | 5.81 |
| CHEMBL4075984 | — | — | 1 | 5.53 |
| CHEMBL4089964 | — | — | 1 | 5.40 |
| CHEMBL4069669 | — | — | 1 | 5.34 |
| CHEMBL4102654 | — | — | 1 | 4.97 |
| CHEMBL4093350 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068870 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4078380 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4087230 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4067480 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4069152 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL2336409 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4075984 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4089964 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL4069669 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL4102654 | — | IC50 | = | 10680.0 | nM | 4.97 |
| CHEMBL4093350 | — | IC50 | = | 17850.0 | nM | 4.75 |