Assay Detail
Functional
CHEMBL4034748
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Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.92 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067408 | — | — | 1 | 6.52 |
| CHEMBL4105005 | — | — | 1 | 5.82 |
| CHEMBL429095 | — | — | 1 | 5.64 |
| CHEMBL4094844 | — | — | 1 | 5.52 |
| CHEMBL4082819 | — | — | 1 | 5.30 |
| CHEMBL4097725 | — | — | 1 | 5.11 |
| CHEMBL4066281 | — | — | 1 | 5.10 |
| CHEMBL4060132 | — | — | 1 | 4.75 |
| CHEMBL4086414 | — | — | 1 | 4.54 |
| CHEMBL4098262 | — | — | 1 | 4.54 |
| CHEMBL4066643 | — | — | 1 | 4.51 |
| CHEMBL4075821 | — | — | 1 | 4.48 |
| CHEMBL4085485 | — | — | 1 | 4.40 |
| CHEMBL4087165 | — | — | 1 | 4.17 |
| CHEMBL4066424 | — | — | 1 | 4.14 |
| CHEMBL4097300 | — | — | 1 | 4.14 |
| CHEMBL4093222 | — | — | 1 | - |
| CHEMBL4104313 | — | — | 1 | - |
| CHEMBL4094178 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067408 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4105005 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL429095 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4094844 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4082819 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4097725 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4066281 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4060132 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4086414 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4098262 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4066643 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4075821 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4085485 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4087165 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4066424 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4097300 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4093222 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4104313 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4094178 | — | IC50 | > | 100000.0 | nM | - |